ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases
2018; American Society for Microbiology; Volume: 63; Issue: 1 Linguagem: Inglês
10.1128/aac.01801-18
ISSN1098-6596
AutoresMichael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, Tatiana Domitrovic, Susan D. Rudin, Sandra S. Richter, David van Duin, Barry N. Kreiswirth, Chris Greco, Derrick E. Fouts, Robert A. Bonomo,
Tópico(s)Bacterial biofilms and quorum sensing
ResumoThe activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.
Referência(s)