Produção Nacional
Revisado por pares
Psidium guajava bioactive product chemical analysis and heavy metal toxicity reduction
2018; Elsevier BV; Volume: 216; Linguagem: Inglês
10.1016/j.chemosphere.2018.10.174
ISSN1879-1298
AutoresCelestina Elba Sobral de Souza, Ana Raquel Pereira da Silva, Nádghia Figueiredo Leite, Janaína Esmeraldo Rocha, Amanda Karine de Sousa, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Francisco Assis Bezerra da Cunha, Larissa Araújo Rolim, Henrique Douglas Melo Coutinho,
Tópico(s)Phytochemistry Medicinal Plant Applications
ResumoThe present study had as its objective to verify the Psidium guajava var. Pomifera L. chelating, antioxidant and cytoprotective effects against mercury and aluminum. The ethanolic extract, tannic and flavonoid fractions were subjected to LC-MS analysis. The Ferric Reducing Antioxidant Power (FRAP) and ferric ion reduction demonstrated a present antioxidant activity. The fungicidal and bactericidal activity of these metals were established. After determining the sub-allelopathic doses, germination tests using Lactuca sativa were performed. Quercetin and its derivatives were the main compounds identified in the extract and the fractions. Mercury chloride significantly reduced the bactericidal effect of the flavonoid fraction (p < 0.001). None of the fractions were cytoprotective against mercury or aluminum in the fungal model assays. Using a sub-allelopathic concentration (64 μg/mL), the ethanolic extract, flavonoid and tannic fractions were found to be cytoprotective against aluminum for radicles, however only the tannic fraction was cytoprotective for caulicles. These data suggest that natural P. guajava products are promising cytoprotective compound sources. This activity may be related to the antioxidant effect of secondary metabolites, mainly flavonoids. Our results point to a potential for environmental intervention product and technique development aimed at mitigating contamination by toxic metals such as mercury and aluminum.
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