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New lignans from the roots of Datura metel L

2018; Elsevier BV; Volume: 28; Linguagem: Inglês

10.1016/j.phytol.2018.08.002

1876-7486

Bing‐You Yang, Yumeng Luo, Yan Liu, Xin Yin, Yuanyuan Zhou, Haixue Kuang,

Cholinesterase and Neurodegenerative Diseases

Two new lignans (1-2) and a new natural product (3), as well as eighteen known compounds (4-21), were isolated from the roots of Datura metel L. Compounds 8, 11, 12, 14, 16, 17, 19 and 21 were isolated from Datura metel L for the first time. These compounds' chemical structures were elucidated by spectroscopic methods, including 1D and 2D NMR spectra with references to the literature, as well as high-resolution mass spectrometric analysis. All compounds were tested for cytotoxic activity using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt etrazolium bromide) assay.