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Evidence of natural Zika virus infection in neotropical non-human primates in Brazil

2018; Nature Portfolio; Volume: 8; Issue: 1 Linguagem: Inglês

10.1038/s41598-018-34423-6

2045-2322

Ana Carolina Bernardes Terzian, Nathália Zini, Lívia Sacchetto, Rebeca Fróes Rocha, Maisa Carla Pereira Parra, Juliana Lemos Del Sarto, Ana Carolina Fialho Dias, Felipe Hernandes Coutinho, Jéssica Rayra, Rafael Alves da Silva, Vivian Vasconcelos Costa, Natália Coelho Couto de Azevedo Fernandes, Rodrigo Albergaria Réssio, Josué Díaz‐Delgado, Juliana Mariotti Guerra, Mariana Sequetin Cunha, José Luiz Catão‐Dias, Cíntia Bittar, Andréia Francesli Negri Reis, Izalco Nuremberg Penha dos Santos, Andréia Cristina Marascalchi Ferreira, Lilian Elisa Arão Antônio Cruz, Paula Rahal, Leila Sabrina Ullmann, Camila Dantas Malossi, João Pessoa Araújo Júnior, Steven G. Widen, Izabela Maurício de Rezende, Érica Munhoz de Mello, Carolina Colombelli Pacca, Erna Geessien Kroon, Giliane S. Trindade, Betânia Paiva Drumond, Francisco Chiaravalloti Neto, Nikos Vasilakis, Mauro Martins Teixeira, Maurício Lacerda Nogueira,

Viral Infections and Vectors

In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.