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High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement

2018; Elsevier BV; Volume: 78; Linguagem: Inglês

10.1016/j.ijid.2018.10.014

1878-3511

M. Montero, Marisa Mir, Elena Sulleiro, J.L. Avalos Esquivel, Enrique García López, Daniel Molina‐Morant, Inmaculada López-Montesinos, Luisa Sorlí, Gerard Espinosa, E. Mounteis Oliva, Marta Crespo, Inés Monge‐Escartín, Juan Pablo Horcajada, S Grau, J. Pascual,

Complement system in diseases

There is little published data on benznidazole dosing, or levels in cerebrospinal fluid. In this report, we describe the clinical course of an immunosuppressed patient with Chagas central nervous system involvement. He was treated successfully with larger benznidazole doses than are recommended, in order to reach therapeutically effective concentrations in the brain.