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RNAcentral: a hub of information for non-coding RNA sequences

2018; Oxford University Press; Volume: 47; Issue: D1 Linguagem: Inglês

10.1093/nar/gky1034

1362-4962

Blake Sweeney, Anton I. Petrov, Boris Burkov, ROBERT FINN, Alex Bateman, M. Szymański, Wojciech M. Karłowski, Jan Gorodkin, Stefan E. Seemann, Jamie J. Cannone, Robin R. Gutell, Petra Fey, Siddhartha Basu, Simon Kay, Guy Cochrane, Konstantinos Billis, David Emmert, Steven J Marygold, Rachael P. Huntley, Ruth C. Lovering, Adam Frankish, Patricia P. Chan, Todd M. Lowe, Elspeth A. Bruford, Ruth L. Seal, Jo Vandesompele, Pieter‐Jan Volders, Maria D. Paraskevopoulou, Lina Ma, Zhang Zhang, Sam Griffiths‐Jones, Janusz M. Bujnicki, Pietro Boccaletto, Judith A. Blake, Carol J. Bult, Runsheng Chen, Yi Zhao, Valerie Wood, Kim Rutherford, Elena Rivas, James H. Cole, Stanley J. F. Laulederkind, Mary Shimoyama, Marc Gillespie, M Orlic-Milacic, Ioanna Kalvari, Eric P. Nawrocki, Stacia R. Engel, J. Michael Cherry, SILVA Team, Tanya Berardini, Artemis G. Hatzigeorgiou, Dimitra Karagkouni, Kevin Howe, Paul Davis, Marcel E. Dinger, Shunmin He, Maki Yoshihama, Naoya Kenmochi, Peter F. Stadler, Kelly P. Williams,

RNA modifications and cancer

RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms. We have recently added a new genome mapping pipeline that identifies genomic locations for ncRNA sequences in 296 species. We have also added several new types of functional annotations, such as tRNA secondary structures, Gene Ontology annotations, and miRNA-target interactions. A new quality control mechanism based on Rfam family assignments identifies potential contamination, incomplete sequences, and more. The RNAcentral database has become a vital component of many workflows in the RNA community, serving as both the primary source of sequence data for academic and commercial groups, as well as a source of stable accessions for the annotation of genomic and functional features. These examples are facilitated by an improved RNAcentral web interface, which features an updated genome browser, a new sequence feature viewer, and improved text search functionality. RNAcentral is freely available at https://rnacentral.org.