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In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

2018; Elsevier BV; Volume: 109; Linguagem: Inglês

10.1016/j.biopha.2018.10.130

1950-6007

Guangjiang Shi, Yan Li, Qiuhua Cao, Hongxi Wu, Xin‐Ying Tang, Xinghua Gao, Jianqiang Yu, Zhen Chen, Yong Yang,

Phytochemicals and Antioxidant Activities

Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Finally, we contemplate future development and application prospects of quercetin. Despite the wealth of in animal research results suggesting the anti-diabetic and its complications potential of quercetin, its efficacy in diabetic human subjects is yet to be explored. The problem may become an important direction in the future research.