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A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.

1991; Springer Nature; Volume: 44; Issue: 8 Linguagem: Inglês

10.7164/antibiotics.44.814

1881-1469

Kanki Komiyama, Shinji Funayama, YUMI ANRAKU, Masami Ishibashi, Yōko Takahashi, Takatoshi Kawakami, Satoshi Ōmura,

Natural product bioactivities and synthesis

A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0μg/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1, 000μg/ml.