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Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

2018; American Association for the Advancement of Science; Volume: 362; Issue: 6417 Linguagem: Inglês

10.1126/science.aar2971

1095-9203

Brett A. Shook, Renee R. Wasko, Guillermo C. Rivera-Gonzalez, Emilio Salazar-Gatzimas, Francesc López‐Giráldez, Biraja C. Dash, Andrés Rojas, Krystal D. Aultman, Rachel K. Zwick, Vivian Lei, Jack L. Arbiser, Kathryn Miller‐Jensen, Damon A. Clark, Henry C. Hsia, Valerie Horsley,

Mesenchymal stem cell research

Myofibroblast diversity with injury and aging Fibroblasts deposit extracellular matrix (ECM) molecules to regulate tissue strength and function. However, if too much ECM is deposited, fibrosis and scarring results. Shook et al. examined cells during mouse skin wound healing, fibrosis, and aging (see the Perspective by Willenborg and Eming). They identified distinct subpopulations of myofibroblasts, including cells identified as adipocyte precursors (APs). In cellular ablation mouse models, CD301b-expressing macrophages selectively activated proliferation of APs, but not other myofibroblasts. Myofibroblast composition and gene expression changed during aging. Thus, macrophage-fibroblast interactions are important during tissue repair and aging, which may have therapeutic implications for chronic wounds and fibrotic disease. Science , this issue p. eaar2971 ; see also p. 891