Produção Nacional
Revisado por pares
In loco retention effect of magnetic core mesoporous silica nanoparticles doped with trastuzumab as intralesional nanodrug for breast cancer
2018; Informa; Volume: 46; Issue: sup3 Linguagem: Inglês
10.1080/21691401.2018.1508030
ISSN2169-141X
AutoresFilipe Leal Portilho, Suyene Rocha Pinto, Aline Oliveira da Silva de Barros, Edward Helal‐Neto, Sofia Nascimento dos Santos, Emerson Soares Bernardes, Derya İlem‐Özdemir, Makbule Aşıkoğlu, Luciana Magalhães Rebêlo Alencar, Clenilton Costa dos Santos, Eduardo Ricci‐Júnior, Félix Sancenón, Ramón Martínez‐Máñez, Ralph Santos‐Oliveira,
Tópico(s)Cancer Cells and Metastasis
ResumoBreast cancer is women's most common type of cancer, with a global rate of over 522,000 deaths per year. One of the main problems related to breast cancer relies in the early detection, as the specialized treatment. In this direction was developed, characterized and tested in vivo a smart delivery system, based on radiolabelled magnetic core mesoporous silica doped with trastuzumab as intralesional nanodrug for breast cancer imaging and possible therapy. The results showed that nanoparticles had a size of 58.9 ± 8.1 nm, with specific surface area of 872 m2/g and pore volume of 0.85 cm3/g with a pore diameter of 3.15 nm. The magnetic core mesoporous silica was efficiently labelled with 99mTc (97.5% ±0.8) and doped >98%. The cytotoxicity assay, demonstrated they are safe to use. The data were corroborated with the IC50 result of: 829.6 µg ± 43.2. The biodistribution showed an uptake by the tumour of 7.5% (systemic via) and 97.37% (intralesional) with less than 3% of these nanoparticles absorbed by healthy tissues. In a period 6-h post-injection, no barrier delimited by the tumour was crossed, corroborating the use as intralesional nanodrug.
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