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Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest

2018; Elsevier BV; Volume: 147; Linguagem: Inglês

10.1016/j.plefa.2018.11.011

1532-2823

Reggie Hui‐Chao Lee, Alexandre Couto e Silva, Harlee E. Possoit, F. Lerner, Po-Yi Chen, Rinata Azizbayeva, Cristiane T. Citadin, Celeste Yin‐Chieh Wu, Jake T. Neumann, Hung Wen Lin,

Neonatal and fetal brain pathology

We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion and remain understudied. Thus, we investigated PAME's role in modulating cerebral blood flow (CBF) and neuroprotection after 6 min of cardiac arrest (model of global cerebral ischemia). Our results suggest that PAME can enhance CBF under normal physiological conditions, while administration of PAME (0.02 mg/kg) immediately after cardiopulmonary resuscitation can also enhance CBF in vivo. Additionally, functional learning and spatial memory assessments (via T-maze) 3 days after asphyxial cardiac arrest (ACA) suggest that PAME-treated rats have improved learning and memory recovery versus ACA alone. Furthermore, improved neuronal survival in the CA1 region of the hippocampus were observed in PAME-treated, ACA-induced rats. Altogether, our findings suggest that PAME can enhance CBF, alleviate neuronal cell death, and promote functional outcomes in the presence of ACA.