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Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

2018; Massachusetts Medical Society; Volume: 379; Issue: 21 Linguagem: Inglês

10.1056/nejmra1704560

1533-4406

Marcus D. Goncalves, Benjamin D. Hopkins, Lewis C. Cantley,

Toxin Mechanisms and Immunotoxins

Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers and is being targeted as a treatment, with notable success in lymphoma.