Artigo Acesso aberto

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

2018; American Association for Cancer Research; Volume: 9; Issue: 2 Linguagem: Inglês

10.1158/2159-8290.cd-18-0715

ISSN

2159-8290

Autores

Kevin Lin, Maria I. Harrell, Amit M. Oza, Ana Oaknin, Isabelle Ray‐Coquard, Anna V. Tinker, Elena Helman, Marc R. Radke, Carmen Say, Lan-Thanh Vo, Elaina Mann, Jeffrey D. Isaacson, Lara Maloney, David M. O’Malley, Setsuko K. Chambers, Scott H. Kaufmann, Clare L. Scott, Gottfried E. Konecny, Robert L. Coleman, James Sun, Heidi Giordano, James D. Brenton, Thomas C. Harding, Iain A. McNeish, Elizabeth M. Swisher,

Tópico(s)

CRISPR and Genetic Engineering

Resumo

A key resistance mechanism to platinum-based chemotherapies and PARP inhibitors in

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