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Plasma Cell–Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients

2018; Oxford University Press; Volume: 5; Issue: 12 Linguagem: Inglês

10.1093/ofid/ofy301

2328-8957

Monica Fung, Simona Zompì, Hon Seng, Desiree Hollemon, Adama Parham, David K. Hong, Sivan Bercovici, Estelle Dolan, Kathy Lien, Justin Teraoka, Aaron C. Logan, Peter Chin‐Hong,

Fungal Infections and Studies

Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell-free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.