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Geroneuroprotectors: Effective Geroprotectors for the Brain

2018; Elsevier BV; Volume: 39; Issue: 12 Linguagem: Inglês

10.1016/j.tips.2018.09.008

1873-3735

David Schubert, António Currais, Joshua Goldberg, Kim D. Finley, Michael Petrascheck, Pamela Maher,

Stress Responses and Cortisol

Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.