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Standardized extract of Erythrina velutina Willd. attenuates schizophrenia-Like behaviours and oxidative parameters in experimental animal models

2018; Oxford University Press; Volume: 71; Issue: 3 Linguagem: Inglês

10.1111/jphp.13039

2042-7158

Kátia Cilene Ferreira Dias, Jamily Cunha de Almeida, Luna Costa Vasconcelos, Marianna Letícia Vasconcelos Patrocínio, Talita Matias Barbosa, Naiara Coelho Ximenes, Ana Paula de Azevedo Leitão, Bianca Oliveira Louchard, Antônia Torres Ávila Pimenta, Francisco das Chagas Lima Pinto, Luzia Kalyne Almeida Moreira Leal, José Eduardo Ribeiro Honório, Silvânia Maria Mendes Vasconcelos,

Bioactive natural compounds

To study the effects of the standardized extract from the leaves of Erythrina velutina in behavioural and oxidative parameters in the ketamine-induced schizophrenia model.Mice received ketamine (KET) or saline for 7 days. From 8th to 14th day, the animals received Erythrine (Eryt) (100, 200 or 400 mg/kg) or olanzapine (Olanz), 1 h after KET administration. At 14th day, 30 min after the last administration of KET, the open-field and pre-pulse inhibition (PPI) tests were performed. Then, the animals were sacrificed and the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the oxidative tests.Ketamine increased spontaneous locomotor activity and grooming. KET decreased the PPI, which was reversed by combining it with Eryt or olanzapine. KET decreased GSH concentration in PFC and ST this was reversed by Eryt. KET increased MDA concentration in PFC and HC this was reversed by Eryt. Eryt and Olanzapine reduced MDA concentration in ST when compared to KET group. Nitrite concentration was reduced by administration of KET in the PFC.These results demonstrate that the standardized extract of E. velutina can prevent behavioural symptoms and oxidative stress induced by repeated doses of KET.