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Dedifferentiated liposarcoma of the gallbladder: first reported case

2018; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês

10.1186/s12957-018-1520-5

1477-7819

A. Costa, Fernando Santa‐Cruz, Brena F. Sena, Ademar Lopes, Nicole Leite, Alexandre Rolim da Paz, Álvaro Antônio Bandeira Ferraz, José Luiz de Figueiredo,

Cancer-related molecular mechanisms research

Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge.A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. The CT report suggested gallbladder liposarcoma. A cholecystectomy associated with resection of segments IV-B and V of the liver were performed. Intraoperative frozen sections were compatible with gallbladder sarcoma. Anatomopathological examination and immunohistochemistry confirmed dedifferentiated liposarcoma with foci of heterologous leiomyosarcomatous differentiation and undifferentiated fusocellular areas of high histological grade.This is the first case of dedifferentiated liposarcoma of the gallbladder to be reported.