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Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

2018; Massachusetts Medical Society; Volume: 380; Issue: 2 Linguagem: Inglês

10.1056/nejmoa1813598

1533-4406

Léon Tshilolo, George Tomlinson, Thomas N. Williams, Brígida Santos, Peter Olupot‐Olupot, Adam Lane, Banu Aygün, Susan E. Stuber, Teresa S. Latham, Patrick T. McGann, Russell E. Ware,

Myeloproliferative Neoplasms: Diagnosis and Treatment

Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safety, and benefits of hydroxyurea in low-resource settings.