Produção Nacional
Revisado por pares
Effect of CYP 4F2 , VKORC 1 , and CYP 2C9 in Influencing Coumarin Dose: A Single‐Patient Data Meta‐Analysis in More Than 15,000 Individuals
2018; Wiley; Volume: 105; Issue: 6 Linguagem: Inglês
10.1002/cpt.1323
ISSN1532-6535
AutoresElisa Danese, Sara Raimondi, Martina Montagnana, Angela Tagetti, Taimour Langaee, Paola Borgiani, Cinzia Ciccacci, Antonio J. Carcas, Alberto M. Borobia, Hoi Y. Tong, Cristina Lucía Dávila-Fajardo, Mariana Rodrigues Botton, Stéphane Bourgeois, Panos Deloukas, Michael D. Caldwell, J. K. Burmester, Richard L. Berg, Larisa H. Cavallari, Katarzyna Drozda, Min Huang, Lizi Zhao, Hanjing Cen, Rocío Gónzález‐Conejero, Vanessa Roldán, Yusuke Nakamura, Taisei Mushiroda, Inna Y. Gong, Richard B. Kim, Keita Hirai, Kunihiko Itoh, Carlos A. Arias, Leonardo Beltrán, Enrique Jiménez-Varo, Marisa Cañadas‐Garre, Alice Giontella, Marianne Kristiansen Kringen, Kari Bente Foss Haug, Hye Sun Gwak, Kyung Eun Lee, Pietro Minuz, Ming Ta Michael Lee, Steven A. Lubitz, Stuart A. Scott, Cristina Mazzaccara, Lucia Sacchetti, Ece Genç, Mahmut Özer, Anil Pathare, Rajagopal Krishnamoorthy, Andràs Páldi, Virginie Siguret, Marie‐Anne Loriot, Vijay Kumar Kutala, Guilherme Suarez‐Kurtz, Jamila Alessandra Perini, Joshua C. Denny, Andrea H. Ramirez, Balraj Mittal, Saurabh Singh Rathore, Hersh Sagreiya, Russ B. Altman, Mohamed H. Shahin, Sherief Khalifa, Nita A. Limdi, Charles Rivers, Aditi Shendre, Chrisly Dillon, Ivet Suriapranata, Honghao Zhou, Shenglan Tan, Vacis Tatarūnas, Vaiva Lesauskaitė, Yumao Zhang, Anke H. Maitland‐van der Zee, Talitha I. Verhoef, Anthonius de Boer, Monica Taljaard, Carlo–Federico Zambon, Vittorio Pengo, Jieying Eunice Zhang, Munir Pirmohamed, Julie A. Johnson, Cristiano Fava,
Tópico(s)Analytical Methods in Pharmaceuticals
ResumoThe cytochrome P450 ( CYP ) 4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta‐analysis at the individual patients level to capture the possible effect of ethnicity, gene—gene interaction, or other drugs on the association and to verify if inclusion of CYP 4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta‐analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients’ data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP 4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval ( CI ) 7–10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP 4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.
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