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Potassium Persulfate‐Mediated Thiocyanation of 2 H ‐Indazole under Iron‐Catalysis

2018; Wiley; Volume: 361; Issue: 4 Linguagem: Inglês

10.1002/adsc.201801232

1615-4169

Amrita Dey, Alakananda Hajra,

Synthesis and Catalytic Reactions

Abstract Potassium persulfate‐mediated thiocyanation of 2 H ‐indazoles has been developed using ammonium thiocyanate as thiocyanating agent under iron‐catalysis at room temperature. 2‐Aryl‐3‐thiocyanato‐2 H ‐indazoles are synthesized in good yields with a broad substrates scope. This methodology is also applicable for the selenocyanation of 2 H ‐indazoles. The mechanistic study suggests the reaction probably proceeds through a radical pathway. magnified image