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Electrochemical Sensing Platform Based on Nano‐Perovskite/Glycine/Carbon Composite for Amlodipine and Ascorbic Acid Drugs

2018; Wiley; Volume: 31; Issue: 3 Linguagem: Inglês

10.1002/elan.201800577

1521-4109

Nada F. Atta, Ekram H. El‐Ads, Ahmed Galal, Aya E. Galal,

Conducting polymers and applications

Abstract People suffered from essential hypertension have increased oxidative stress. Thus, adding vitamin C to their medical therapy resulted in decreasing the oxidative stress and increasing the antioxidant status. This may prevent further vascular damage due to the oxidative stress, leading to a better diagnosis in critical hypertension patients. A novel sensor was fabricated based on NdFeO 3 nano‐perovskite/glycine/carbon nanotubes modified carbon paste electrode in presence of sodium dodecyl sulfate; GLNFCNTCP‐SDS for electrochemical sensing and simultaneous determination of antihypertensive and antioxidant drugs, Amlodipine (AML) and ascorbic acid. The developed nanocomposite showed interactive characteristics of all the modifiers as high conductivity, enhanced surface area, surface fouling resistance and stability. This leads to accelerated electron transfer rate and increased current response of electro‐oxidation of AML by 8.3 folds compared to unmodified electrode. The method validity was investigated successfully by the quantitative analysis of AML in human urine samples and Norvasc tablets with acceptable recovery results. The featured merits of the proposed composite in the analysis of AML in human urine samples were; wide concentration range of 0.003 μmol L −1 to 200 μmol L −1 , sensitivity of 113.2 μA/μmol L −1 , detection limit of 0.704 nmol L −1 , and quantification limit of 2.35 nmol L −1 .