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Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes

2018; Elsevier BV; Volume: 8; Linguagem: Inglês

10.1016/j.cophys.2018.11.008

2468-8681

Marin Manuel, Daniel Zytnicki,

Cardiomyopathy and Myosin Studies

The field of motoneuron and motor unit physiology in mammals has deeply evolved the last decade thanks to the parallel development of mouse genetics and transcriptomic analysis and of in vivo mouse preparations that allow intracellular electrophysiological recordings of motoneurons. We review the efforts made to investigate the electrophysiological properties of the different functional subtypes of mouse motoneurons, to decipher the mosaic of molecular markers specifically expressed in each subtype, and to elucidate which of those factors drive the identity of motoneurons.