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Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

2018; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 1 Linguagem: Inglês

10.3390/biom9010001

2218-273X

Sanjay Shrestha, Mark Hazelbaker, Amber L. Yount, Claire Walczak,

Ubiquitin and proteasome pathways

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.