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Rhabdoviruses, Antiviral Defense, and SUMO Pathway

2018; Multidisciplinary Digital Publishing Institute; Volume: 10; Issue: 12 Linguagem: Inglês

10.3390/v10120686

1999-4915

Faten El Asmi, Carlos Eduardo Brantis-de-Carvalho, Danielle Blondel, Mounira K. Chelbi‐Alix,

Toxoplasma gondii Research Studies

Small Ubiquitin-like MOdifier (SUMO) conjugation to proteins has essential roles in several processes including localization, stability, and function of several players implicated in intrinsic and innate immunity. In human, five paralogs of SUMO are known of which three are ubiquitously expressed (SUMO1, 2, and 3). Infection by rhabdoviruses triggers cellular responses through the activation of pattern recognition receptors, which leads to the production and secretion of interferon. This review will focus on the effects of the stable expression of the different SUMO paralogs or Ubc9 depletion on rhabdoviruses-induced interferon production and interferon signaling pathways as well as on the expression and functions of restriction factors conferring the resistance to rhabdoviruses.