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Vascular Oxidative Stress: Impact and Therapeutic Approaches

2018; Frontiers Media; Volume: 9; Linguagem: Inglês

10.3389/fphys.2018.01668

1664-042X

Cristina M. Sena, Adriana Leandro, Lara Azul, Raquel Seiça, George Perry,

Eicosanoids and Hypertension Pharmacology

Oxidative stress is an imbalance between oxidants and antioxidants or better a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlight different strategies to inhibit ROS production.