Artigo Acesso aberto Revisado por pares

Regioselective Transition-Metal-Free Oxidative Cyclobutanol Ring Expansion to 4-Tetralones

2018; American Chemical Society; Volume: 20; Issue: 24 Linguagem: Inglês

10.1021/acs.orglett.8b03619

ISSN

1523-7060

Autores

Philipp Natho, Mia Kapun, Lewis A. T. Allen, Philip J. Parsons,

Tópico(s)

Chemical Synthesis and Analysis

Resumo

A facile and transition-metal-free ring expansion of the cyclobutanol moiety to 4-tetralones fused to heteroaromatic systems is described. The oxidative ring expansion proceeds rapidly and regioselectively through mediation by N-bromosuccinimide and acetonitrile in satisfactory to good yields. The preparation of precursors and the ring expansion have proven to be scalable and are straightforward to carry out.

Referência(s)