Produção Nacional
Revisado por pares
Synthesis, Antioxidant Activity and Cytotoxicity of N-Functionalized Organotellurides
2018; Elsevier BV; Volume: 27; Issue: 2 Linguagem: Inglês
10.1016/j.bmc.2018.12.017
ISSN1464-3391
AutoresPamela T. Bandeira, Mara C. Dalmolin, Mariana Maciel de Oliveira, Karine Campos Nunes, Francielle Pelegrin Garcia, Celso Vataru Nakamura, Alfredo R. M. Oliveira, Leandro Piovan,
Tópico(s)Organic Chemistry Cycloaddition Reactions
ResumoThe use of antioxidants is the most effective means to protect the organism against cellular damage caused by oxidative stress. In this context, organotellurides have been described as promising antioxidant agents for decades. Herein, a series of N-functionalized organotellurium compounds has been tested as antioxidant and presented remarkable activities by three different in vitro chemical assays. They were able to reduce DPPH radical with IC50 values ranging from 5.08 to 19.20 µg mL−1, and some of them also reduced ABTS+ radical and TPTZ-Fe3+ complex in ABTS+ and FRAP assays, respectively. Initial structure-activity relationship discloses that the nature of N-substituent strongly influenced both activity and cytotoxicity of the studied compounds. Furthermore, radical scavenging activities of N-functionalized organotellurides have been compared with those of their selenilated congeners, demonstrating that the presence of tellurium atom has an essential role in antioxidant activity.
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