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Therapeutic bullfrog oil-based nanoemulsion for oral application: Development, characterization and stability

2018; De Gruyter Open; Volume: 69; Issue: 1 Linguagem: Inglês

10.2478/acph-2019-0001

1846-9558

Renata Rutckeviski, Francisco Humberto Xavier Júnior, Andreza Rochelle do Vale Morais, Lucas Amaral-Machado, Éverton do Nascimento Alencar, Julieta Genre, Adriano Antunes de Souza Araújo, Eryvaldo Sócrates Tabosa do Egito,

Food Chemistry and Fat Analysis

The aim of this study was to develop, optimize, and characterize a stable therapeutic bullfrog oil based nanoemulsion for oral application using a rational experimental design approach. The optimized oral nanoemulsion contained 0.2 % sodium benzoate and 0.02 % propyl-paraben as preservatives; 0.1 % sucralose and 0.4 % acesulfam K as sweeteners and 0.1 % tutti-frutti as flavoring to mask the unpleasant organoleptic characteristics of bullfrog oil. The oral O/W-nanoemulsion showed the droplet size, PDI, zeta potential, and pH of 410 ± 8 nm, 0.20 ± 0.02, -38 ± 2.5 mV, and 6.43 ± 0.05, respectively. The optimized oral nanoemulsion showed a milky single-phase and optimal physical stability at 25 °C for 90 days. Indeed, higher oxidation induction time and lower formation of peroxides in the oral nanoemulsion were responsible for improving its stability. A therapeutic delivery system containing bullfrog oil for oral application was successfully developed and optimized with ideal thermo-oxidative stability.