Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

2018; Oxford University Press; Volume: 57; Issue: 7 Linguagem: Inglês

10.1093/mmy/myy112

1460-2709

Caroline Maria Marcos, Haroldo César de Oliveira, Patrícia Akemi Assato, Cléverton Roberto de Andrade, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini,

Plant Disease Resistance and Genetics

The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.