Produção Nacional
Revisado por pares
The role of sphingosine‐1‐phosphate in skeletal muscle: Physiology, mechanisms, and clinical perspectives
2018; Wiley; Volume: 234; Issue: 7 Linguagem: Inglês
10.1002/jcp.27870
ISSN1097-4652
AutoresAndré V. Cordeiro, Vagner Ramon Rodrigues Silva, José Rodrigo Pauli, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Eduardo R. Ropelle,
Tópico(s)Autophagy in Disease and Therapy
ResumoSphingolipids were discovered more than a century ago and were simply considered as a class of cell membrane lipids for a long time. However, after the discovery of several intracellular functions and their role in the control of many physiological and pathophysiological conditions, these molecules have gained much attention. For instance, the sphingosine-1-phosphate (S1P) is a circulating bioactive sphingolipid capable of triggering strong intracellular reactions through the family of S1P receptors (S1PRs) spread in several cell types and tissues. Recently, the role of S1P in the control of skeletal muscle metabolism, atrophy, regeneration, and metabolic disorders has been widely investigated. In this review, we summarized the knowledge of S1P and its effects in skeletal muscle metabolism, highlighting the role of S1P/S1PRs axis in skeletal muscle regeneration, fatigue, ceramide accumulation, and insulin resistance. Finally, we discussed the physical exercise role in S1P/S1PRs signaling in skeletal muscle cells, and how this nonpharmacological strategy may be prospective for future investigations due to its ability to increase S1P levels.
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