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Immune Context Characterization and Heterogeneity in Primary Tumors and Pulmonary Metastases from Renal Cell Carcinoma

2018; Future Medicine; Volume: 11; Issue: 1 Linguagem: Inglês

10.2217/imt-2018-0097

1750-7448

Melissa Bersanelli, Letizia Gnetti, Elena Varotti, Luca Ampollini, Paolo Carbognani, Francesco Leonardi, Michele Rusca, Nicoletta Campanini, Francesco Ziglioli, Clara Indira Dadomo, Francesco Paolo Pilato, Alessio Cortellini, Elena Rapacchi, Giuseppe Caruso, Enrico Maria Silini, Umberto Maestroni, Sebastiano Buti,

Cancer Genomics and Diagnostics

Aim: The knowledge of the immune context of renal cell carcinoma (RCC) is useful to predict benefit from immunotherapy. We retrospectively characterized the immune context of RCC patients underwent primary nephrectomy and pulmonary metastasectomy. Materials & methods: Intratumoral infiltrating lymphocytes and peritumoral renal infiltrating lymphocytes, lymphocyte subpopulations (CD4+, CD8+), PD-1, PD-L1 were explored in paired samples of primary RCC (T) and respective pulmonary metastases (M). Results: The immune variables demonstrated intralesional and intratumoral heterogeneity. Intralesional lymphocyte heterogeneity reached 76% of cases in T, 28% in M. The heterogeneity rate for PD-L1 expression was from 44% (T) to 56% (M); it correlated with better survival. Conclusion: The immune context of RCC is highly variable both within a given tumor and among primary and metastases.