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Potential clinical applications of circulating cell-free DNA in ovarian cancer patients

2018; Cambridge University Press; Volume: 20; Linguagem: Inglês

10.1017/erm.2018.5

1462-3994

Ana Paula Fernandes Barbosa, Ana Peixoto, Pedro Pinto, Manuela Pinheiro, Manuel R. Teixeira,

Renal cell carcinoma treatment

Abstract Circulating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential clinical applications of cfDNA in ovarian cancer patients.