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Hepatitis B vaccination coverage among healthcare workers at a tertiary hospital in Rwanda

2018; BioMed Central; Volume: 11; Issue: 1 Linguagem: Inglês

10.1186/s13104-018-4002-5

1756-0500

Claude Mambo Muvunyi, Jean De Dieu Harelimana, Osée Sebatunzi, Aschariya Chinma Atmaprakash, Eric Seruyange, Florence Masaisa, Olivier Manzi, Martin Nyundo, Théobald Hategekimana,

Hepatitis C virus research

We evaluated post-vaccination immunity status and describe potential risk factors associated with the lack of response among healthcare workers (HCWs) at a tertiary care hospital in Kigali, Rwanda. Of 373 HCWs, 291 (78.2%) were female and 81 (21.8%) were male. The mean age of the study participants was 40.2 years (standard deviation [SD], 7.7 years), within a range of 24–41 years. Participants' mean BMI was 25.4 ± 6.6 kg/m2, with more than half of patients (60.3%) being overweight. 96% received all three doses of vaccination. A total of 36 participants (9.6%) were considered non responders as they did not develop a sufficient anti-HBs response post vaccination. The anti-HBs response was significantly higher in females when compared to males (p = 0.02). Interestingly, there was no significant association between decline in antibody levels with age (p = 0.242) and BMI (p = 0.516) of the participants. The anti-HBs titers were similar in the group of participants who had received two doses and those who had received three doses of the HBV vaccination. Overall the findings of our study provide a basis for testing for anti-HBs in all HCWs post vaccination in Rwanda.