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Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer

2018; Wiley; Volume: 41; Issue: 2 Linguagem: Inglês

10.1002/hed.25459

1097-0347

Pihla Pakkanen, Leena‐Maija Aaltonen, Timo Sorsa, Taina Tervahartiala, Jaana Hagström, Taru Ilmarinen,

Blood Coagulation and Thrombosis Mechanisms

Abstract Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP. Methods We analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow‐up. Results Elevated S‐MMP‐8 level in RRP was associated with malignant transformation ( P = .01). Compared to patients with RRP, S‐MMP‐8 in patients with LSCC was significantly higher ( P < .001). Increased S‐TIMP‐1 level in LSCC was associated with poor overall survival ( P = .02) and recurrence‐free survival ( P = .05). Conclusion In RRP, high S‐MMP‐8 may predict malignant transformation. In LSCC, elevated S‐TIMP‐1 is connected to poor survival.