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Phenolic compounds from Virola venosa (Myristicaceae) and evaluation of their antioxidant and enzyme inhibition potential

2018; INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; Volume: 49; Issue: 1 Linguagem: Inglês

10.1590/1809-4392201800832

1809-4392

Kamila Rangel Primo Fernandes, Paulo Senna BITTERCOURT, Afonso Duarte Leão de Souza, Antônia Queiroz Lima de Souza, Felipe M. A. da Silva, Émerson Silva Lima, Leonard Domingo Rosales Acho, Rita de Cássia Saraiva Nunomura, Ana Frazão Teixeira, Héctor H. F. Koolen,

Bee Products Chemical Analysis

ABSTRACT Virola venosa, popularly known in Brazil as ucuuba-da-mata, occurs naturally in the Amazon region and has potential to provide useful natural compounds, as already known for other Virola species. Therefore, the objective of this study was to determine the chemical composition of bark and leaf extracts of V. venosa, and to test the antioxidant capacity and α-glucosidase inhibition potential of their compounds. Polar extracts showed to be more active in both assays, therefore a bioactivity-guided fractionation was performed to identify the compounds that were responsible for the recorded activities. Using a combination of LC-MS/MS analysis and isolation with NMR identification, eight phenolic compounds were identified. Assays with pure compounds of the active fraction revealed that ferulic acid was the main contributor compound to the observed bioactivity in the crude extracts.