Portal de Periódicos da CAPES

Integrating Genomics into Healthcare: A Global Responsibility

2019; Elsevier BV; Volume: 104; Issue: 1 Linguagem: Inglês

10.1016/j.ajhg.2018.11.014

1537-6605

Zornitza Stark, Lena Dolman, Teri A. Manolio, Brad Ozenberger, Sue Hill, Mark J. Caulfied, Yves Lévy, David Glazer, Julia L. Wilson, Mark Lawler, Tiffany Boughtwood, Jeffrey Braithwaite, Peter Goodhand, Ewan Birney, Kathryn N. North,

BRCA gene mutations in cancer

Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation. Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.