Produção Nacional
Revisado por pares
Synthetic Approaches to Organoselenium Derivatives with Antimicrobial and Anti-Biofilm Activity
2018; Bentham Science Publishers; Volume: 16; Issue: 6 Linguagem: Inglês
10.2174/1570193x16666181227111038
ISSN1875-6298
AutoresIris Di Leo, Federica Messina, Vanessa Nascimento, Francesca Giulia Nacca, Donatella Pietrella, Eder J. Lenardão, Gelson Perin, Luca Sancineto,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoIn the recent years, an increasing attention has been given to the biological activities exerted by organoselenium compounds. In 1984, Sies reported for the first time the ability of ebselen to mimic the activity of glutathione peroxidase. From this milestone, several studies reported the pharmacological properties of selenium-containing compounds including their exploitation as antimicrobials. In this context, this minireview presents the most recent examples of seleno derivatives endowed with antimicrobial activities while discussing the most interesting and recent synthetic procedures used to obtain these compounds.
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