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VITAMIN D CONTENT IN POPULATION OF RADIOLOGICALLY CONTAMINATED AREAS IN CHERNIVTSI OBLAST (pilot project)

2018; Volume: 23; Linguagem: Inglês

10.33145/2304-8336-2018-23-442-451

2313-4607

O. V. Kaminskyi, V.І. Pankiv, І.V. Pankiv, D. Afanasyev,

Human Health and Disease

To study the status of vitamin D in population of Chernivtsi region living on the radioactively contami-nated territories.In a cross-sectional study under a pilot project the 180 people aged 19 to 78 years old per-manently residing in 3 regions of Chernivtsi oblast, namely in the village of Kyseliv in Kitsman district, which isattributed to the IIIrd zone of radiololgical contamination due to the Chornobyl catastrophe, as well as in the cityof Chernivtsi and the city of Vyzhnytsia were surveyed in summer. Assay of the 25(OH)D in blood serum was per-formed using the immune chemiluminescence method «ECLIA» on the Elecsys 2010 (Roche Diagnostics, Germany)analyzer using Cobas test systems.The average level of 25(OH)D in serum was (16.2 ± 0.8) ng/mL, the incidence of vitamin D deficiency was46.9%, and the incidence of vitamin D lack was 53.8%. Severe vitamin D deficiency has been detected in 6 cases inthe village of Kyseliv. At the same time, its share among the surveyed in this region was the highest (11.5%) beingsignificantly different from the proportion of severe deficits in Chernivtsi and Vyzhnytsia. A reliable correlationbetween the body mass index (BMI) and the blood serum level of 25(OH)D was found among persons with BMI of25-29.9 kg/m2. At the same time, the average value of 25(OH)D level among obese subjects (BMI greater than30 kg / m2) was practically the same as in subjects with normal body mass.Content of vitamin D was significantly lower among the population of radiologically contaminatedarea vs. the inhabitants of Chernivtsi and Vyzhnytsia. Status of vitamin D among the population of Chernivtsi regionremains far from optimal and requires urgent action for correction and prevention.Meta: vyvchyty status vitaminu D u naselennia Chernivets'koï oblasti, shcho prozhyvaie na radioaktyvno zabrudnenykhterytoriiakh.Materialy i metody: v odnomomentnomu doslidzhenni (pilotnyĭ proekt) v litniu poru obstezheno 180 osib vikomvid 19 do 78 rokiv, iaki postiĭno prozhyvaiut' u tr'okh regionakh Chernivets'koï oblasti (s. Kyseliv Kitsmans'kogoraĭonu, iake vidneseno do III zony radiatsiĭnogo zabrudnennia vnaslidok Chornobyl's'koï katastrofy, a takozh m.Chernivtsi i m. Vyzhnytsia). Vyznachennia rivnia 25(OH)D u syrovattsi krovi obstezhenykh osib provodyly za dopomogoiuimunokhemiliuminestsentnogo metodu «ECLIA» na analizatori Elecsys 2010 (Roche Diagnostics, Nimechchyna) iz vyko-rystanniam test-system Sobas.Rezul'taty. Seredniĭ riven' 25(ON)D u syrovattsi krovi u meshkantsiv radiatsiĭno zabrudnenoï zony stanovyv(16,2-#177;0,8) ng/ml, chastota defitsytu vitaminu D – 46,9 %, chastota nedostatnosti vitaminu D – 53,8 %. Tiazhkyĭdefitsyt vitaminu D vyiavleno u 6 obstezhenykh iz s. Kyseliv. Pry ts'omu sered obstezhenykh ts'ogo regionu ĭogo chast-ka bula naĭvyshchoiu (11,5 %) i virogidno vidriznialasia v porivnianni z chastkoiu tiazhkogo defitsytu u obstezhenykh izChernivtsiv ta Vyzhnytsi. Vstanovlena dostovirna koreliatsiia mizh indeksom masy tila (IMT) ta rivnem 25(ON)D u sy-rovattsi krovi sered osib z IMT 25–29,9 kg/m2. U toĭ zhe chas serednie znachennia rivnia 25(OH)D sered osib zozhyrinniam (IMT ponad 30 kg/m2) praktychno ne vidriznialosia vid pokaznykiv osib z normal'noiu masoiu tilaVysnovky: vmist vitaminu D vyiavyvsia dostovirno nyzhchym sered naselennia, iake prozhyvaie na radiatsiĭno zabrud-neniĭ terytoriï, u porivnianni z meshkantsiamy Chernivtsiv i Vyzhnytsi. Status vitaminu D sered naselennia Chernivets'-koï oblasti zalyshaiet'sia dalekym vid optymal'nogo i potrebuie nevidkladnykh diĭ shchodo korektsiï i profilaktyky.