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Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012–2015)

2019; Nature Portfolio; Volume: 9; Issue: 1 Linguagem: Inglês

10.1038/s41598-018-36799-x

2045-2322

Catarina Silva-Costa, Maria João Brito, Sandra I. Aguiar, Joana P. Lopes, Mário Ramirez, José Melo‐Cristino, Teresa Vaz, Marília Gião, Rui Ferreira, Ana Bruschy Fonseca, Henrique Oliveira, Ana Cristina Silva, Hermínia Costa, Maria Fátima Silva, Maria Amélia Afonso, Margarida Pinto, Odete Chantre, João Gaspar Marques, Isabel Peres, Isabel Daniel, Ema Canas, Teresa Ferreira, Cristina Marcelo, Lummy Monteiro, Luís Lito, Filomena Martins, Maria Ana Pessanha, Elsa Gonçalves, Teresa Morais, Teresa Marques, Cristina Toscano, Paulo Lopes, Luísa Felício, Angelina Lameirão, Ana Paula Mota Vieira, Margarida Tomaz, Rosa Bento, Maria Helena Ramos, Ana Paula Castro, Fernando Fonseca, Ana Paula Castro, Graça Ribeiro, Rui Tomé Ribeiro, Celeste Pontes, Luísa Boaventura, Catarina Chaves, Teresa Reis, Nuno Canhoto, Teresa Afonso, Teresa Casas, Helena Peres, Ilse Fontes, Paulo N. Martinho, Ana Domingos, Gina Marrão, José Grossinho, Manuela Ribeiro, Helena Gonçalves, Alberta Faustino, Adelaide Alves, Maria Cármen Iglesias, Maria Paula Pinheiro, R. Semedo, Adriana Coutinho, Luísa Cabral, Olga Neto, Luísa Sancho, José Diogo, Ana Carolina Rodrigues, Isabel Nascimento, Elmano Ramalheira, Fernanda Lopes Bessa, Raquel Diaz, Isabel Vale, Ana Carvalho, José Miguel Ribeiro, Maria Antónia Read, Valquíria Alves, Margarida Monteiro, Engrácia Raposo, Maria Lurdes Magalhães, Helena Rochas, Anabela G. Silva, Margarida Rodrigues, José Mota Freitas, Sandra I. Vieira, Maria Meneses, Germano de Sousa, Mariana Bettencourt Viana, Isaura Terra, Vitória Eduarda Silva Rodrigues, Patrícia Pereira, Jesuína Duarte, Paula Pinto, Ezequiel Moreira, J. A Ferreira, Adília Vicente, Paulo Paixão, Natália Novais, Sónia Aires, Cristina Ferreira, Eurico Gaspar, Manuela Ferreira, Fernanda G. Pereira, Maria José Dinis, Álvaro Sousa, Paulo José Zimermann Teixeira, José Amorim, Cláudia Dias Monteiro Toma, Isabel Carvalho, Sofia Arosa, Margarida Guedes, Lino Marques, Ana Cristina Braga, Margarida Tavares, Isabel Cristina Kowal Olm Cunha, Lurdes Vicente, Maria Manuel Zarcos, Helena Almeida, Sílvia Almeida, Fernanda Rodrigues, Cristina Resende, Eulália Afonso, Luìsa Mendes, Cristina Faria, Ana Luísa Teixeira, Antonio M. Mendes, Teresa Tomé, Mónica Rebelo, Filomena Moreira Pinto Pereira, Gustavo Rodrigues, A. K. F. M. Costa, Ana P. Teixeira, Sofia A. Costa Lima, Érica Laima, Maria Ana Sampaio Nunes, Filipa Prata, Pedro Flores, Manuela Brandão, João Calado Nunes, Rosário Massa, Florbela Cunha, Paula Correia, Anabela Brito, J. Lorenzo Franco, Cristina Didelet, Estela Veiga, Carla Cruz, Graça Seves, Céu Novais, Maria João Virtuoso, Nancy Guerreiro, Amélia Cavaco, Francisco A. M. Gomes, Dora Gomes, Isabel Monteiro,

Respiratory viral infections research

We evaluated the impact of continued 13-valent pneumococcal conjugate vaccine (PCV13) use in the private market (uptake of 61%) in pediatric invasive pneumococcal disease (pIPD) in Portugal (2012-2015). The most frequently detected serotypes were: 3 (n = 32, 13.8%), 14 (n = 23, 9.9%), 1 (n = 23, 9.9%), 7F (n = 15, 6.4%), 19A (n = 13, 5.6%), 6B and 15B/C (both n = 12, 5.2%), and 24F, 10A and 12B (all with n = 10, 4.3%). Taken together, non-PCV13 serotypes were responsible for 42.2% of pIPD with a known serotype. The use of PCR to detect and serotype pneumococci in both pleural and cerebrospinal fluid samples contributed to 18.1% (n = 47) of all pIPD. Serotype 3 was mostly detected by PCR (n = 21/32, 65.6%) and resulted from a relevant number of vaccine failures. The incidence of pIPD varied in the different age groups but without a clear trend. There were no obvious declines of the incidence of pIPD due to serotypes included in any of the PCVs, and PCV13 serotypes still accounted for the majority of pIPD (57.8%). Our study indicates that a higher vaccination uptake may be necessary to realize the full benefits of PCVs, even after 15 years of moderate use, and highlights the importance of using molecular methods in pIPD surveillance, since these can lead to substantially increased case ascertainment and identification of particular serotypes as causes of pIPD.