Nasal-Associated Lymphoid Tissue
2005; Elsevier BV; Linguagem: Inglês
10.1016/b978-012491543-5/50027-9
Autores Tópico(s)Immunotherapy and Immune Responses
ResumoMost characteristics found for Peyer's patch (PP) M cells are attributable to those in nasal-associated lymphoid tissue (NALT)—with slight regional differences such as binding patterns of lectins. NALT is an important inducive site of immune responses after nasal immunization. Immunization via the nose is an effective way to induce mucosal immune responses at remote effector sites, and the NALT plays an important role in the induction of these responses. The preferential switching to IgA is an apparent characteristic of humoral immune responses elicited through the nose and is reflected by the presence of IL-6–producing T cells in the NALT after immunization. The NALT is equipped with a unique machinery to enrich for high-affinity IgA cells in the memory compartment. NALT is not only an important site for IgA induction, but is also capable of generating cytotoxic activity. Intrinsic capacities of cervical lymph nodes—particularly the superficial cervical and internal jugular—are instrumental for the mode of antigen presentation by specialized antigen-presenting cells to T cells, eventually leading to active immunologic tolerance.
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