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BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

2019; Elsevier BV; Volume: 21; Issue: 8 Linguagem: Inglês

10.1038/s41436-018-0406-9

1530-0366

Andrew Lee, Nasim Mavaddat, Amber N. Wilcox, Alex Cunningham, Tim Carver, Simon Hartley, Chantal Babb de Villiers, À. Izquierdo, Jacques Simard, Marjanka K. Schmidt, Fiona M Walter, Nilanjan Chatterjee, Montserrat García‐Closas, Marc Tischkowitz, Paul D.P. Pharoah, Douglas F. Easton, Antonis C. Antoniou,

Cancer Genomics and Diagnostics

Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk model to incorporate the effects of polygenic risk scores (PRS) and other risk factors (RFs).