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Lipids and polymers in pharmaceutical technology: Lifelong companions

2019; Elsevier BV; Volume: 558; Linguagem: Inglês

10.1016/j.ijpharm.2018.12.080

1873-3476

Juergen Siepmann, Amina Faham, Sophie-Dorothée Clas, Ben J. Boyd, Vincent Jannin, Andreas Bernkop‐Schnürch, Hang Zhao, Sébastien Lecommandoux, James Evans, Christine Allen, Olivia M. Merkel, Gabriella Costabile, Morgan R. Alexander, Ricky Wildman, Clive J. Roberts, Jean‐Christophe Leroux,

Nanoparticle-Based Drug Delivery

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Annual Scientific Meeting of the Gattefossé Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.