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Competing risks of major bleeding and thrombotic events with prasugrel-based dual antiplatelet therapy after stent implantation - An observational analysis from BASKET-PROVE II

2019; Public Library of Science; Volume: 14; Issue: 1 Linguagem: Inglês

10.1371/journal.pone.0210821

1932-6203

Raban Jeger, Matthias Pfisterer, D. Vogt, Søren Galatius, Ulrik Abildgaard, Christoph Naber, Hannes Alber, Franz R. Eberli, David J. Kurz, Giovanni Pedrazzini, André Vuilliomenet, Daniel Weilenmann, Hans Rickli, Kim Wadt Hansen, Peter Rickenbacher, David Conen, Christian Müller, Stefan Osswald, Nicole Gilgen, Christoph Kaiser,

Acute Myocardial Infarction Research

Background Dual antiplatelet therapy (DAPT) prevents thrombotic events after coronary stent implantation but may induce bleedings, specifically in elderly patients. However, a competitive risk analysis is lacking. Objectives To assess the determinants of major bleeding and the balance between the competing risks of major bleeding and thrombotic events during prasugrel-based DAPT after stent implantation. Methods Overall, 2,291 patients randomized to drug-eluting or bare metal stents and treated with prasugrel 10mg/day for 1 year were followed over 2 years for major bleeding (BARC 3/5) and thrombotic events (cardiac death, myocardial infarction, definitive/probable stent thrombosis). Prasugrel dose was reduced to 5mg in patients >75 years and/or <60kg. Predictors of major bleeding and competing risks of major bleeding and thrombotic events were assessed. Results Two-year rates of major bleeding and thrombotic events were 2.9% and 9.0%, respectively. The only independent predictor of major bleeding was age (hazard ratio per year increase 1.05 [1.02,1.07], p 65 years. In younger patients, thrombotic events represent a higher risk than bleeding, while thrombotic and bleeding risks were similar in older patients. Important clinical implications relate to prasugrel dose in the elderly, duration of DAPT and the competing risk balance necessitating individualized treatment decisions.