Produção Nacional
Revisado por pares
Phenolic compounds from Tocoyena bullata mart (Rubiaceae) with inhibitory activity in mast cells degranulation
2019; Taylor & Francis; Volume: 34; Issue: 22 Linguagem: Inglês
10.1080/14786419.2018.1560281
ISSN1478-6427
AutoresFabiana M. Santos, Camila Adão Malafaia, Daniel Luiz Reis Simas, Aline Barreto Paulino, Michelle Frazão Muzitano, Naomi Kato Simas, Elaine A. Cruz Da-Rocha, Ana Cláudia F. Amaral, Ivana Corrêa Ramos Leal,
Tópico(s)Plant biochemistry and biosynthesis
ResumoGlycosylated flavonoids, caffeoylquinic acid and 3,5-dicaffeoylquinic acid have been identified in the ethyl acetate partition from the crude ethanol extract of Tocoyena bullata (Rubiaceae) leaves. The fraction containing the mixture of flavonol rutin and a tetraglycosylated flavonoid showed 89.2% inhibition and the mixture of isoquercitrin and 3,5-dicaffeoylquinic acid showed 88.5% inhibition of mast cell degranulation. These results demonstrated that the tetraglycosylated flavonoid, rutin, isoquercitrin and 3,5-dicaffeioylquinic acid were the most promising phenolics for inhibition of mast cell degranulation. For the first time the identification of phenolic constituents and their correlation with inhibitory effect on mast cell degranulation were reported in this work
Referência(s)