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The Multifaceted B Cell Response to Influenza Virus

2019; American Association of Immunologists; Volume: 202; Issue: 2 Linguagem: Inglês

10.4049/jimmunol.1801208

1550-6606

Jonathan Lam, Nicole Baumgarth,

Immune Cell Function and Interaction

Abstract Protection from yearly recurring, highly acute infections with a pathogen that rapidly and continuously evades previously induced protective neutralizing Abs, as seen during seasonal influenza virus infections, can be expected to require a B cell response that is too highly variable, able to adapt rapidly, and able to reduce morbidity and death when sterile immunity cannot be garnered quickly enough. As we outline in this Brief Review, the influenza-specific B cell response is exactly that: it is multifaceted, involves both innate-like and conventional B cells, provides early and later immune protection, employs B cells with distinct BCR repertoires and distinct modes of activation, and continuously adapts to the ever-changing virus while enhancing overall protection. A formidable response to a formidable pathogen.