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In vitro solar protection factor, antioxidant activity, and stability of a topical formulation containing Benitaka grape ( Vitis vinifera L.) peel extract

2019; Taylor & Francis; Volume: 34; Issue: 18 Linguagem: Inglês

10.1080/14786419.2018.1550758

1478-6427

Letícia Caramori Cefali, Janaína Artem Ataide, Ilza Maria de Oliveria Sousa, Mariana Cecchetto Figueiredo, Ana Lúcia Tasca Góis Ruiz, Mary Ann Foglio, Priscila Gava Mazzola,

Essential Oils and Antimicrobial Activity

A flavonoid enriched extract (FE) was obtained from grape peels, and in vitro SPF, antioxidant activity, and effects on cell viability of this extract were tested with the intent to develop a cosmetic product. A formulation was developed with the FE, and the stability of this mixture was evaluated in terms of pH, density, viscosity, and SPF (90-days). FE showed no cytotoxicity to human keratinocytes and an in vitro SPF of 18.56 (UV-spectrophotometry). Further, FE showed a UVA protection factor of 3.17 ± 0.2, a critical wavelength of 318.0 ± 0.1 and a UVA/UVB of 0.9. Antioxidant activity assays resulted in 92.08% and 86.85% of activity against DPPH and ABTS (IC50 = 296.90 ± 1.2 µg/mL and 643.13 ± 0.9 µg/mL), respectively. Finally, SPF of formulation with FE was 12.45. Results from the in vitro SPF and product stability tests (especially storage under refrigeration), indicate that FE is a promising compound for use as an innovative sunscreen formulation.