Produção Nacional
Revisado por pares
Cardiovascular Effect of Diosgenin in Ovariectomized Rats
2019; Mary Ann Liebert, Inc.; Volume: 22; Issue: 3 Linguagem: Inglês
10.1089/jmf.2018.0019
ISSN1557-7600
AutoresIlmara Cecilia Pinheiro de Silva Morais, Iris Jordânia Luz Moura, Carla Kelly Barroso Sabino, Lucas Antônio Duarte Nicolau, Fabiana de Moura Souza, José Couras da Silva‐Filho, Rita de Cássia Meneses Oliveira, Jand Venes Rolim Medeiros, Sidney Gonçalo de Lima, Aldeídia Pereira de Oliveira,
Tópico(s)Cardiovascular, Neuropeptides, and Oxidative Stress Research
ResumoDiosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200-220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10
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