Produção Nacional
Revisado por pares
The effect of solution environment and the electrostatic factor on the crystallisation of desmotropes of irbesartan
2019; Royal Society of Chemistry; Volume: 9; Issue: 9 Linguagem: Inglês
10.1039/c8ra10146a
ISSN2046-2069
AutoresAndrea Mariela Araya‐Sibaja, Mariola Urgellés, Felipe Vásquez-Castro, Felipe Vargas-Huertas, José Roberto Vega‐Baudrit, Teodolíto Guillén-Girón, Mirtha Navarro-Hoyos, Sílvia L. Cuffini,
Tópico(s)Crystallization and Solubility Studies
ResumoThe experimental conditions necessary for stabilising irbesartan (IBS) tautomers in solution and selectively obtaining the desmotropic crystal forms are presented herein. 1H and 2H tautomers were stabilized in specific solution conditions and the 2H-tetrazole⋯imidazole interaction was confirmed by solution-state NMR. The results showed that highly polar and polarisable solvents (higher values of the electrostatic factor (EF)) lead to the crystallisation of IBS form B. Furthermore, the variations of pH in methanol, in turn, determined the crystallisation of desmotropes A and/or B.
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