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Myoepithelioma‐like tumor of the vulvar region showing infiltrative growth and harboring only a few estrogen receptor‐positive cells: A case report

2019; Wiley; Volume: 69; Issue: 3 Linguagem: Inglês

10.1111/pin.12765

1440-1827

Yui Kojima, Mikiko Tanabe, Ikuma Kato, Toru Motoi, Mariko Kimura, Tomoe Sawazumi, Reiko Tanaka, Sawako Chiba, Masako Otani, Yoshiaki Inayama,

Tumors and Oncological Cases

Recently, a new entity “myoepithelioma‐like tumor of the vulvar region (MELTVR)” was proposed as a rare mesenchymal neoplasm arising in vulvar regions of adult women. While MELTVRs morphologically resemble soft tissue myoepitheliomas and extraskeletal myxoid chondrosarcomas, they have a unique immunohistochemical profile (positive for epithelial membrane antigen and estrogen receptor, negative for S100 protein and glial fibrillary acidic protein, and loss of INI1/SMARCB1 expression), and lack EWSR1 and NR4A3 gene rearrangement, as seen by fluorescence in situ hybridization. MELTVRs are usually well‐demarcated tumors, with no reports of extensive infiltrative growth. In the current report, we present an unusual case of MELTVR showing infiltrative growth and harboring only a few estrogen receptor‐positive cells, which might indicate a variation in this rare tumor.