Ligand-Free Iron-Catalyzed Carbon (sp 2 )–Carbon (sp 2 ) Oxidative Homo-Coupling of Alkenyllithiums
2019; American Chemical Society; Volume: 21; Issue: 3 Linguagem: Inglês
10.1021/acs.orglett.8b03893
ISSN1523-7060
AutoresZhuliang Zhong, Zhiyong Wang, Shao‐Fei Ni, Li Dang, Hung Kay Lee, Xiao‐Shui Peng, Henry Ν. C. Wong,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoA new strategy was developed for the efficient synthesis of di-, tetra-, and hexa-substituted 1,3-butadienes. This one-pot procedure involves lithium-iodine exchange to generate the corresponding vinyllithium intermediates. A subsequent iron-catalyzed ligand-free oxidative homo-coupling eventually led to the formation of 1,3-butadienes in acceptable to excellent isolated yields.
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